Kim Clijsters waved goodbye to Wimbledon on Monday after she was thrashed 6-1, 6-1 by German eighth seed Angelique Kerber.
The world number two decided she had insufficient time to get fit for the last Grand Slam of the year.
"Right now I am mentally and physically tired," said Clijsters after being beaten in the Swisscom Challenge semi-finals by Jelena Dokic.
Belgian Kim Clijsters crowned her remarkable comeback by beating Caroline Wozniacki of Denmark 7-5, 6-3 to win the US Open women's title on Sunday.
The Belgian was beaten by Russia's Svetlana Kuznetsova in the semi-finals of the Warsaw WTA claycourt event.
Kim Clijsters won her second straight Grand Slam title and the fourth of her career beating China's Li Na to clinch the Australian Open crown on Saturday.
Kim Clijsters beat Dinara Safina, while Mary Pierce downed Tatiana Golovin in the semi-final of the Paris Open.
The world number two was on crutches after sustaining a bruised bone in her foot at the Hopman Cup in Perth earlier this month.
World number six Kim Clijsters returned from a two-month injury layoff to beat Luxembourg's Anne Kremer 6-3 6-2 in the first round of the Hasselt Cup on Wednesday.
The 20-year-old Belgian won her fourth title at the Luxembourg Open in the past five years.
If winning the US Open ever came down to a popularity contest, Kim Clijsters would be roared to victory every time.
The Belgian top seeds remained on course to meet in the final of the Swisscom Challenge.
Fourth seed Kim Clijsters overcame a late wobble to beat Slovakian Daniela Hantuchova 6-1 7-5 on Monday and set up a mouth-watering Australian Open quarter-final against Martina Hingis.
The Belgian battled past Jelena Jankovic 5-7, 6-2, 6-2 in the second round of the Bank of the West Classic
The French Open champion was forced to retire during the Ordina Open final because of a wrist injury.
Kim Clijsters beat Russian Svetlana Kuznetsova 7-5, 6-2 to win the Warsaw Cup
Her elaborate outfit required years of Nike production planning, with crystals proving particularly challenging on performance wear. The dramatic hair change after walking out onto the court was always part of the plan.
Belgium's Kim Clijsters will become world number one next week for the first time since 2006 after she reached the Paris Open semi-finals by beating Jelena Dokic 6-3, 6-0 on Friday.
Roger Federer lost his first tiebreak this year before beating Arnaud Clement as he began his title defence at the Nasdaq-100 Open.
World number two Kim Clijsters has confirmed she will make her comeback from a two-month injury layoff at the French Open, the Belgian said on Monday.
Former world number one Kim Clijsters will play about 16 tournaments next year including all four Grand Slams, the 26-year-old Belgian said on Thursday.
Elena Dementieva lost 6-4, 6-2 to Italy's Francesca Schiavone at the WTA Championships on Friday before stunning the crowd by announcing her retirement from tennis.
Australian Open champion Kim Clijsters plans to play on for a maximum two years following her remarkable run of success since returning to the tour in 2009 after taking time out to have a baby.
Kim Clijsters recovered from a set down to beat Li Na 3-6, 6-3, 6-3 to win the Australian Open on Saturday after the Chinese imploded under pressure in the second set and took out her frustrations on her country's fans.
Kim Clijsters is unlikely to defend her US Open title later this month because of a wrist injury.
The Belgian won 7-6, 6-3 to earn a meeting with Russian second seed Svetlana Kuznetsova in the semi-finals of the WTA event in Warsaw.
Belgium's Kim Clijsters downed Maria Sharapova 6-3, 7-5 to win the Nasdaq-100 Open and claim her second consecutive title
Belgium's Kim Clijsters reached the US Open final on Saturday after defending champion Serena Williams was defaulted on the final point. Clijsters won the match 6-4 7-5, which ended in controversy when the American was called for a foot-fault on a second serve to go match point down. An angry Williams argued with the lineswoman who reported her for verbal abuse. She will meet Caroline Wozniacki of Denmark, who beat error-prone Belgian Yanina Wickmayer 6-3, 6-3.
The Belgian beat Wimbledon champion Venus Williams for her third Stanford Classic title.
Belgian Kim Clijsters made a successful return from a long injury absence on Wednesday, overcoming dogged Czech Iveta Benesova 7-6, 6-2 in the second round of the Belgian Open.
Clijsters says she hopes she has discovered the "magic formula" to beating the Williams sisters.
Champion Kim Clijsters has pulled out of the US Open due to a stomach muscle injury. 'Two weeks of rehab was not enough to heal this injury,' said the Belgian said in a statement, released by the USTA on Friday.
Kim Clijsters, making her comeback on Monday after a two-year absence, has the same dream as when she was world number one -- to win Wimbledon.
The World number ones were named top seeds for next week's U.S. Open.
